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Premature and low birth weight newborns with congenital heart defects

Compared to term and normal birth weight neonates, these patients are at increased risk of morbidity and mortality. The aim of this study is to analyse clinical and epidemiological factors associated with the timing of surgery in preterm and LBW newborns.

The results of this retrospective multi-centre study will help optimise future decision-making to further improve the long-term developmental neurological outcome of preterm and LBW newborns with CHD.

 

Study director

Prof. Bettina Reich

Department of Paediatric Cardiology and Congenital Heart Defects

German Heart Centre Munich

 

Duration

June 2021 to December 2021

 

Participating scientists

Prof. Walter Knirsch

Dr Cornelia Hagmann

Children’s Hospital Zurich

Cardiology

Steinwiesstrasse 75

8032 Zurich

 

Dr Joppe Nijman

Paediatric Intensive Care Unit

University Medical Centre Utrecht

PO Box 85500

3508 GA Utrecht

 

Literature

Andrews RE, Simpson JM, Sharland GK, Sullivan ID, Yates RW. 2006. Outcome after preterm delivery of infants antenatally diagnosed with congenital heart disease. J Pediatr 148: 213-6

Dees E, Lin H, Cotton RB, Graham TP, Dodd DA. 2000. Outcome of preterm infants with congenital heart disease. J Pediatr 137: 653-9

Jennings E, Cuadrado A, Maher KO, Kogon B, Kirshbom PM, Simsic JM. 2012. Short-term outcomes in premature neonates adhering to the philosophy of supportive care allowing for weight gain and organ maturation prior to cardiac surgery. J Intensive Care Med 27: 32-6

Norman M, Hakansson S, Kusuda S, Vento M, Lehtonen L, et al. 2020. Neonatal Outcomes in Very Preterm Infants With Severe Congenital Heart Defects: An International Cohort Study. J Am Heart Assoc 9: e015369

Polito A, Piga S, Cogo PE, Corchia C, Carnielli V, et al. 2013. Increased morbidity and mortality in very preterm/VLBW infants with congenital heart disease. Intensive Care Med 39: 1104-12

Shepard CW, Kochilas LK, Rosengart RM, Brearley AM, Bryant R, 3rd, et al. 2010. Repair of major congenital cardiac defects in low-birth-weight infants: is delay warranted? J Thorac Cardiovasc Surg 140: 1104-9