Start » Molecular genetics of atherosclerosis and myocardial infarction working group

Further information

Zhifen Chen, PhD
Tan An Dang, M.Sc.
Dr Alexander Dutsch
Dr Ulrich Güldener
Shichao Pang, PhD
Dr Johann Hawe
Dr Moritz von Scheidt

 

Ganildo Cepele
Elisabeth Haag
Louise Hegge
Carolin Höhne
Laura Lambrecht
Constanze Lehertshuber
Ling Li, M.Sc.
Chuhua Yang
Shuangyue Li
Philipp Müller
Amin Sharifi
Michael Winkler

 

Manuela Decker (decker@dhm.mhn.de)
Michaela Frint (frint@dhm.mhn.de)

Wolfgang Latz
Ulrike Weiss
Christopher Wolf
Sven Duscha

Bavarian Ministry of Health
DigiMed Bayern (since 2019)
Corona Foundation in the
Junior Research Group Donors’ Association Translational Cardiovascular Genomics (since

2018)
Deutsches Zentrum für Herz- und Kreislauferkrankungen (DZHK) e.V.
Munich Heart Alliance (since 2012)
Fondation Leducq – Transatlantic Networks of Excellence
CAD Genomics – Understanding coronary artery disease genes (until 2018)
Plaqomics (since 2018)
ERA-CVD
Druggable-MI-genes (since 2018)
EU, The seventh framework programme
CVgenes@target (until 2016)
BMBF, research consortia on systems medicine
e:AtheroSysMED (until 2016)
AbCD-Net (since 2017)
German Research Foundation
SFB 1123, Project B02 (since 2014)
TRR 267, Project B06 (since 2019)

10 key publications (members of the working group first/last author) since 2015

  1. Kessler T, et al. ADAMTS-7 inhibits re-endothelialization of injured arteries and promotes vascular remodelling via cleavage of thrombospondin-1. Circulation 2015, 131, 1191-1201.
  2. Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia Investigators, et al. Coding variation in ANGPTL4, LPL, and SVEP1 and risk of coronary disease. N Engl J Med 2016, 374, 1134-44.
  3. Nelson CP, et al. Association analyses based on false discovery rate implicate many new loci for coronary artery disease. Nat Genet 2017, 49, 1385-1391.
  4. Kessler T, et al. Functional characterization of the GUCY1A3 coronary artery disease risk locus. Circulation 2017, 136, 476-489.
  5. Hall KT*, Kessler T*, et al. Genetic variation at the coronary artery disease risk locus GUCY1A3 modifies cardiovascular disease prevention effects of aspirin. Eur Heart J 2019, 40, 3385-3392.
  6. Zeng L, et al. Genetically modulated educational attainment and coronary disease risk. Eur Heart J 2019, 40, 2413-2420.
  7. Zeng L, et al. Contribution of Gene Regulatory Networks to Heritability of Coronary Artery Disease. J Am Coll Cardiol 2019, 73, 2946-2957.
  8. Winkler M, et al. Functional investigation of the coronary artery disease gene SVEP1. Basic Res Cardiol 2020, 115, 67.
  9. von Scheidt M, et al. The Transcription Factor MAFF Regulates an Atherosclerosis Relevant Network Connecting Inflammation and Cholesterol Metabolism. Circulation 2021, in press.
  10. Wierer M, et al. A proteomic atlas of the neointima identifies novel druggable targets for preventive therapy. Eur Heart J 2021, in press.

Further publications can be found at PubMed (Schunkert,Kessler).