Ongoing projects

• Molecular basis of hypertrophic cardiomyopathyGeneric term for various, often genetically determined diseases of the heart muscle that are not the result of other diseases (heart valve defects, inflammations). The causes of this are often unknown. The heart may be significantly enlarged and its pumping power greatly reduced. in Noonan syndromeCertain signs of the disease occurring together in combination.
• Immunomodulatory signalling pathways in hypertrophic cardiomyopathy
• Genetic modulation of redox signalling pathways in a mouse model of hypertrophic cardiomyopathy
• Genetic predictors of systemic pulmonary arteryArtery supplying the lungs. shuntA natural or surgically created short-circuit connection between normally unconnected areas (e.g. between two vessels). malfunction
• Long-term outcome after septal myectomy in infancy for hypertrophic obstructive cardiomyopathy
• Low-molecular-weight heparin administration via subcutaneousUnder the skin (injection). permanent catheter as an alternative to intravenous(abbr. i.v.) into a vein, e.g. injection, infusion. unfractionated heparin continuous infusionAdministration of fluid (e.g. electrolyte solutions) into a vein; sometimes enriched with medication or important energy sources (artificial nutrition). in patients with congenitalCongenital. heart defects
• Clinical course of hypertrophic cardiomyopathy in Noonan syndrome
• Characterisation of regulatory elements of gene expression for the protein titin in induced pluripotent stem cells
• Molecular mechanisms of right heart failure in congenital heart disease
• Clinical course, outcome and genetic diagnosis in children and adolescents with congenital arrhythmia(Lat.: irregular sequence) Is considered a collective term for disorders of the regular, rhythmic heartbeat sequences. This includes all pulse sequences that are not regular: phases of pulse beats at different speeds, pauses, skips or additional beats. syndromes
• Rhythm events in spiroergometric examinations of patients with complex structural heart defects as predictors of sudden cardiac deathA type of death associated mainly with cardiac rhythm disorders. Causes: sudden onset of rapid heartbeat sequence, such as ventricular tachycardia, ventricular fibrillation, ventricular flutter, or more rarely severe slowing of the heartbeat sequence, but also vascular occlusion, myocardial rupture or total AV block.

Prizes

German Heart Foundation, Gerd Killian Prize
Clinical course and molecular causes of hypertrophic cardiomyopathy in Noonan syndrome

Will Webster Award In Pediatric Electrophysiology for Young Investigators
Reversibility of PRKAG2 glycogen-storage cardiomyopathy and electrophysiological manifestations”.

House Officer Research Award, Society for Pediatric Research, Pediatric Academic Societies
A mouse model of cardiac conduction systemIn the heart muscle there are special, electrically active cells for the formation and transmission of electrical impulses. A collection of such cells in the right atrium forms the sinus node, the “pacemaker” of the heart. From here, electrical impulses are regularly “fired” and transported to the muscle cells via special pathways (conduction system). The muscle cells “respond” to these electrical impulses with a contraction, i.e. they contract. The coordinated contraction of all the heart muscle cells produces the pumping motion of the heart (systole). An ECG can be used to show the development and course of the electrical impulses. disease in laminopathies

New England Electrophysiology Society, Fellows’ Abstract Competition Award
Disappearance of pre-excitation in glycogen storage cardiomyopathy with arresting of PRKAG2 transgene expression”

Sponsorships

Else-Kröner Research College
Immunomodulatory signalling pathways in hypertrophic cardiomyopathy