Research results
In 2002, the successful cooperation between the nuclear medicine department with adult cardiology in the field of infarct diagnostics was continued. Adult cardiology also started participating in a multi-centre study with infarct patients treated in hypothermia. The scintigraphic data is further entered into the scientific database of adult cardiology by an experienced MTA from the Institute.
There was also cooperation with the paediatric cardiology department in nuclear medicine, where joint evaluations were carried out on patients with a condition following surgical treatment of a transposition of the great arteries using a radionuclide ventriculogram, and the effect of the Fontan circulation in lung perfusionFlow through with fluid (e.g. organs are perfused with blood). scintigraphyImaging procedure for detecting circulatory disorders of the heart muscle in coronary heart disease. was also investigated in another patient group. Corresponding publications have appeared or are in preparation.
In the field of nuclear medicine, an extensive doctoral thesis has been in progress since 2002; here, the gated SPECT analysis on the E-Cam is correlated with various software tools in collaboration with adult cardiology with their cardiac catheter data during cardiac scintigraphic examinations.
The newly commissioned multi-slice CT has become well established in the hospital, both in clinical and scientific settings, and is revolutionising cardiac and vascularConcerning the blood vessels. imaging. Corresponding scientific questions are dealt with in the field of electrophysiology (anatomy of the left atriumTerm for the uppermost chambers of the heart. There is a left atrium and a right atrium. The right atrium collects the oxygen-poor blood that flows back from the body to the heart; the left atrium collects the oxygen-rich blood that comes from the lungs. From the atria, the blood continues to the respective ventricles.) and coronaryConcerning the coronary vessels that supply blood to the heart muscle. imaging.
Extensive studies comparing cardiac catheterisationA diagnostic procedure in which a catheter (thin plastic tube) is inserted into the veins (right heart catheter) or arteries (left heart catheter). These are advanced to the inside of the heart. They are used, for example, to measure blood pressure and oxygen content in the various heart chambers or to image the coronary vessels and heart chambers using a contrast medium. and cardiac CT were applied for at the Federal Office for Radiation Protection in 2002. Questions relating to surgical atrial fibrillationHeart rhythm disorder in which both atria beat irregularly more at than 300 times per minute. However, the excitation is only partially transmitted to the ventricles. ablationDestruction of congenital, additional conduction pathways that cause cardiac rhythm disturbances. This is performed with the help of heat generation through cardiac catheters. are also dealt with together with cardiac surgery. All of these scientific projects are carried out in intensive interdisciplinary cooperation.
In the angiology sector, the cooperation with the Vascular Centre rechts der Isar and Neurology was continued, with scientific evaluation of the effects of carotid stent implantationInsertion of a stent. on brain perfusion and possible side effects being carried out here.
For the area of development, the introduction of the new flat-panel detector technology in thoracic diagnostics should be mentioned.
Publications
Finck T, Hardernberg J, Will A, Hendrich E, Haller B, Martionff M, Hausleiter J, Hadamitzky M.
Ten-year follow-up after coronary computed tomography angiographyImaging of blood vessels using contrast medium and X-ray examination. in patients with suspected coronary arteryA blood vessel leading away from the heart that transports oxygenated blood to the organs. Arteries pulsate and can be palpated on the wrist, for example (pulse). The aorta is the main artery of the body. disease. JACC Cardiovasc Imaging. 2018 (in press)
Rutz T, Ghandour F, Meierhofer C, Naumann S, Martinoff S, Lange R, Ewert P, Stern HC, Fratz S.
Evolution of right ventricularArising from the ventricle. size over time after tetralogy of Fallot(TOF) Congenital complex heart defect, named after the French physician Etienne Fallot and consisting of a large, short-circuit connection between the ventricles of the heart (VSD), a malposition of the body’s aorta and a narrowing in the area of the outflow tract of the right ventricle (RVOTO). This can lead to reduced blood flow in the lungs. Sufferers of this condition have a blue-red colour of the face (cyanosis). repair: a longitudinal cardiac magnetic resonance study. Eur Heart J Cardiovasc Imaging. 2017 Mar 1;18(3):364-370.
Stern H, Calavrezos L, Meierhofer C, Steinlechner E, Müller J, Hager A, Martinoff S, Ewert P, Fratz S.
Physical exercise reduces aortic regurgitationRefers to leakage of the aortic valve. Can be congenital (very rare) or an acquired valvular defect. In this case, the aortic valve leaks and the blood flows from the aorta back into the left ventricle during the slackening phase of the heart. The most common cause is shrinkage of the “pockets” that make up the flap. The reasons for this can be inflammation and calcification. The defective valve can be replaced with an artificially manufactured heart valve.: exercise magnetic resonance imaging. JACC Cardiovasc Imaging. 2014 Mar;7(3):314-5.
Hadamitzky M, Langhans B, Hausleiter J, Sonne C, Byrne RA, Mehilli J, Kastrati A, Schömig A, Martinoff S, Ibrahim T.
Prognostic value of late gadolinium enhancement in cardiovascular magnetic resonance imaging after acute ST-elevation myocardial infarctionSee heart attack. in comparison with single-photon emission tomography using Tc99m-Sestamibi. Eur Heart J Cardiovasc Imaging. 2014 Feb;15(2):216-25.
Meierhofer C, Schneider EP, Lyko C, Hutter A, Martinoff S, Markl M, Hager A, Hess J, Stern H, Fratz S.
Wall shear stress and flow patterns in the ascending aortaThe main major artery in the body. Leads from the left ventricle via an arch in the thoracic cavity to the abdominal cavity. There it splits into two large iliac arteries. in patients with bicuspid aortic valves differ significantly from tricuspid aortic valves: a prospective study. Eur Heart J Cardiovasc Imaging. 2013 Aug;14(8):797-804.
Hadamitzky M, Täubert S, Deseive S, Byrne RA, Martinoff S, Schömig A, Hausleiter J.
Prognostic value of coronary computed tomography angiography during 5 years of follow-up in patients with suspected coronary artery disease. Eur Heart J. 2013 Nov;34(42):3277-85.
Hadamitzky M, Achenbach S, Al-Mallah M, Berman D, Budoff M, Cademartiri F, Callister T, Chang HJ, Cheng V, Chinnaiyan K, Chow BJ, Cury R, Delago A, Dunning A, Feuchtner G, Gomez M, Kaufmann P, Kim YJ, Leipsic J, Lin FY, Maffei E, Min JK, Raff G, Shaw LJ, Villines TC, Hausleiter J; CONFIRM Investigators.
Optimized prognostic score for coronary computed tomographic angiography: results from the CONFIRM registry (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter Registry). J Am Coll Cardiol. 2013 Jul 30;62(5):468-76.
Hausleiter J, Meyer TS, Martuscelli E, Spagnolo P, Yamamoto H, Carrascosa P, Anger T, Lehmkuhl L, Alkadhi H, Martinoff S, Hadamitzky M, Hein F, Bischoff B, Kuse M, Schömig A, Achenbach S.
Image quality and radiation exposure with prospectively ECG-triggered axial scanning for coronary CT angiography: the multicenter, multivendor, randomized PROTECTION-III study. JACC Cardiovasc Imaging. 2012 May;5(5):484-93.
Hadamitzky M, Langhans B, Hausleiter J, Sonne C, Kastrati A, Martinoff S, Schömig A, Ibrahim T.
The assessment of area at risk and myocardial salvage after coronary revascularization in acute myocardial infarctionIf the blood supply to an organ or part of an organ is interrupted (arterial occlusion due to thrombosis, embolism), the affected cells die and this area is gradually replaced with connective tissue. An infarction leads to a weakening of organ function, e.g. after a heart attack the pumping action of the heart is restricted.: comparison between CMR and SPECT. JACC Cardiovasc Imaging. 2013 Mar;6(3):358-69.
Hausleiter J, Martinoff S, Hadamitzky M, Martuscelli E, Pschierer I, Feuchtner GM, Catalán-Sanz P, Czermak B, Meyer TS, Hein F, Bischoff B, Kuse M, Schömig A, Achenbach S.
Image quality and radiation exposure with a low tubeVentilation tube voltage protocol for coronary CT angiography results of the PROTECTION II Trial. JACC Cardiovasc Imaging. 2010 Nov;3(11):1113-23.
Hadamitzky M, Freissmuth B, Meyer T, Hein F, Kastrati A, Martinoff S, Schömig A, Hausleiter J.
Prognostic value of coronary computed tomographic angiography for prediction of cardiac events in patients with suspected coronary artery disease. JACC Cardiovasc Imaging. 2009 Apr;2(4):404-11.
Fratz S, Schuhbaeck A, Buchner C, Busch R, Meierhofer C, Martionff M, Hess J, Stern H
Comparison of Accuracy of Axial Slices Versus Short-Axis Slices for Measuring Ventricular Volumes by Cardiac Magnetic Resonance in Patients With Corrected Tetralogy of Fallot. J Am Coll Cardiol. 2009 June; 1ß3(12):1764-69
Hausleiter J, Meyer T, Hermann F, Hadamitzky M, Krebs M, Gerber TC, McCollough C, Martinoff S, Kastrati A, Schömig A, Achenbach S. Estimated radiation dose associated with cardiac CT angiography. JAMA. 2009 Feb 4;301(5):500-7.
