This is an inflammation of the inner skin of the heart (endocardium), which lines the heart cavities and forms the structure of the heart valves. Mostly bacteria are the cause, more rarely fungi. Endocarditis caused by viruses is not known. Symptoms: Fever over a longer period of time, cardiac rhythm disorders and cardiac insufficiency. People with congenital heart defects are particularly at risk (see endocarditis prophylaxis). Endocarditis can lead to acquired heart defects, especially valve defects in adulthood.